Idiopathic Hypersplenism

The megakaryocytes in idiopathic thrombocytopenic purpura, a form of hypersplenism.

An adult girl, robust, without manifest cause, was attacked recently, towards the period of her menses, with a sudden severe hemorrhage from the nose, with bright but foul blood escaping together with a bloody vomiting of a very thick extremely black blood. Immediately there appeared about the neck and on the arms, spots partly black, partly violaceous or purple, such as are often seen in malig...

Hypersplenism in cirrhosis.

Hypersplenism: History and current status

Hypersplenism is a common disorder characterized by an enlarged spleen which causes rapid and premature destruction of blood cells. This review summarizes the history of hypersplenism, discuss its classification and pathogenesis, and examines its diagnosis and treatment options. We performed a comprehensive literature search using PubMed, Web of Knowledge and the China National Knowledge Infras...

Splenomegaly, hypersplenism, and hereditary disorders with splenomegaly

Splenomegaly, sometimes of massive extent, occurs in a large number of hereditary diseases, some relatively prevalent and others, rare to ultra-rare. Because physicians are often unfamiliar with the less common disorders, patients may suffer because of diagnostic delay or diagnostic error and may undergo invasive, non-innocuous procedures such as splenectomy that are potentially avoidable were ...

Life-threatening hypersplenism due to idiopathic portal hypertension in early childhood: case report and review of the literature

BACKGROUND Idiopathic portal hypertension (IPH) is a disorder of unknown etiology and is characterized clinically by portal hypertension, splenomegaly, and hypersplenism accompanied by pancytopenia. This study evaluates the pathogenic concept of the disease by a systematic review of the literature and illustrates novel pathologic and laboratory findings. CASE PRESENTATION We report the first ...